The charged particle activation analysis (CPAA) technique has been applied for quantitative estimation of Zr, Cr and Cu simultaneously in copper alloy. An ion beam of 13 MeV proton was found to be suitable to use (p,n) nuclear reaction channel in CPAA. The optimization of irradiation conditions were performed to apply instrumental approach by minimizing the production of matrix activity. The results of CPAA have been compared with those obtained by using instrumental neutron activation analysis and energy dispersive X-ray fluorescence techniques. Analysis of variance test indicated the statistical parity of the results obtained in the above mentioned three methods.