In this reports, we have synthesized and characterized the palladium catalyst [Pd2(dppf)2(SC12H8S)]2(OTf)4 which is successfully applied for Carbonylative Suzuki-Miyaura cross-coupling reaction. Synthesized catalyst was characterized by various analytical techniques such as 1H NMR, 31P NMR, CHNS, and single crystal X-ray diffraction. The use of Co2(CO)8 as a C1 source instead of gaseous CO is an additional advantage of the developed protocol. The current protocol showing excellent catalytic activity at ppm level of “Pd” concentration to provided high TON and TON. TON could be achieved up to 104 and TOF up to 103. The protocol could tolerate a variety of functional groups and provided wide substrate scope including Heteroaryl ketones. The practical applicability of the proposed protocol up to gram level with marginal loss of the yield of the product. Remarkably, we have synthesized (4-methoxyphenyl) (3,4,5-trimethoxyphenyl)methanone and oxybenzone which is pharmaceutically active drug molecules under co-catalyst, and additive free condition. .