Heavy ion activation of natural silver foil with 48 MeV 7Li results in the formation of carrier-free 109-111Sn along with their corresponding decay products, 109-111In radionuclides, in the matrix. The carrier-free indium radionuclides have been separated from the bulk target matrix silver by employing liquid-liquid extraction as well as supported liquid membrane method using Aliquat-336 as liquid anion exchanger.