BARC/PUB/2002/0086

 
 

Stereo- and regioselectivity in Diels-Alder reactions of 1,3-azaphospholo[5,1-a] isoquinoline and -[1,5-a]pyridine

 
     
 
Author(s)

Bansal, R. K.; Jain, V. K.; Gupta, N.; and others
(NM&SCD)

Source

Tetrahedron, 2002. Vol. 58 (8): pp. 1573-1579

ABSTRACT

1,3-Bis(ethoxycarbonyl)-1,3-azaphospholo[5,1-a] isoquinoline and -[1,5-a]pyridine undergo stereo selective Diels - Alder reactions at the >C= P- functionality with 2,3-dimethylbutadiene and isoprene in the presence of sulfur or methyl iodide. The reaction with isoprene occurs regioselectively as well, as confirmed by an X-ray crystal structure determination of one cycloadduct. Semiempirical PM3 calculations also support the regioselectivity.

 
 
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