BARC/PUB/2019/0221

 
 

A chemoenzymatic synthesis of ceramide trafficking inhibitor HPA-12

 
     
 
Author(s)

Kanojia, S. V.; Chatterjee, S.; Chattopadhyay, S.; Goswami, D.
(BOD)

Source

Beilstein Journal of Organic Chemistry, 2019. Vol. 15: pp. 490-496

ABSTRACT

A chemoenzymatic synthesis of the title compound has been developed using an efficient and highly enantioselective lipase-catalyzed acylation in a hydrophobic ionic liquid, [bmim][PF6], followed by a diastereoselective asymmetric dihydroxylation as the key steps for incorporating the stereogenic centers. The further conversion to the appropriate intermediates and subsequent acylation with lauric acid furnished the target compound.

 
 
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