The modulation of the cyclooxygenase-independent pathway by black tea (BT) and its constituent theafl avins (TFs) during their healing action against indomethacin-induced stomach ulceration in mice was investigated. On the 3^rd day of its administration, indomethacin (18 mg/kg) induced maximum stomach ulceration, which was associated with increased myeloperoxidase (MPO) activity (93.3%, p < 0.001), and inducible nitric oxide synthase (iNOS) expression (1.6-fold, p< 0.001), along with augmented levels of serum nitrite (1.5-fold, p< 0.001), selectins and cell adhesion molecules (CAMs), as well as reduced endothelial nitric oxide synthase (eNOS) expression (60%, p < 0.001). Treatment with BT (40 mg/kg) and TF (1 mg/kg) for 3 days reversed these parameters and provided excellent (78 – 81%) ulcer healing. However, alterations of NOS expressions and levels of selectins and CAMs were only partially responsible for the excellent healing capacity ( ∼ 80%) of omeprazole (3 mg/kg X 3 days).