⁹⁰Y, a beta emitting radionuclide (T_1/2 ~ 64 h, E_max= 2.3 MeV), the daughter product of ⁹⁰Sr is used for radio therapeutic applications. Non dispersive solvent extraction in hollow fibre membrane contactor (HFMC) with CMPO solvent studies were done to achieve the desired purification of ⁹⁰Sr nitrate solution with respect to gross alpha activity. This purified solution is promising feed for ⁹⁰Sr–⁹⁰Y generator to achieve the clinical grade product of ⁹⁰Y. In HFMC recirculations, around 99.97% alpha impurities were extracted in two recirculations from the feed solution with 0.2 M CMPO while only two recirculations were required with 0.4 M CMPO. A simplified mathematical model has also been developed to model the extraction of alpha impurities through the HFMC using CMPO as a solvent.