Different feed and strip operating modes have been compared for the transport of neodymium (Nd3+) and uranyl (UO22+) ions in nitric acid media. The flux values of UO22+ for feed in recycling and once through mode with fresh strip were 2.26×10−9 kmol/m2-s and 2.33×10−9 kmol/m2-s, respectively. So, this resulted in low separation factors. The flux values of Nd3+ for feed and strip—both in recycling and in once through mode—were 2.21×10−9 kmol/m2-s and 2.14×10−9 kmol/m2-s, respectively. The operating modes—feed and strip both recycling and feed and strip both in once through—were found to be the best configurations.