Arsenic (As) poses a significant concern to the environment and human health due to its toxicity and carcinogenic properties. Arsenic contamination of water and soil has significantly increased recently in India and other Asian countries via both man-made and natural sources. Along with drinking water, rice intake, which is a key staple meal for a huge population worldwide, is another common way to be exposed to arsenic. Arsenic contamination leads to negative impact on growth and yield of cultivated crops and also puts the consuming population at risk. Exploring different methods to effectively reduce As from water, soil, and rice plants is urgently needed to maintain the safety of food and a healthy environment. To ensure food safety and healthy environment, it is urgently required to explore various approaches to mitigate As from water, soil and rice plants efficiently. Understanding the nature of As contamination and its uptake is a crucial step in designing suitable strategies to limit the As levels in rice grains. Arsenic mitigation approach is also dependent on various factors i.e., the biogeochemical characteristics of agro-ecosystems, water management techniques, socio-economic situation of the area and cost. This review article expands on research gaps and discusses various agronomical approaches leading to safer rice production.