BARC/PUB/2021/0751

 
 

Facile on-site quality monitoring of alcohol based hand sanitizers by phase separation and color development with butyl acetate-crystal violet mixture

 
     
 
Author(s)

Thangavel, S.; Durgaprasad, A.; Dash, K.; Sanjiv Kumar
(CCCM)

Source

Microchemical Journal, 2021. Vol. 169: Article no. 106578

ABSTRACT

Amidst the unprecedented demand for alcohol based hand sanitizers in the wake of the continuing onslaught of COVID-19 pandemic, a simple and rapid method for identifying spurious or non-conforming products is the need of the hour. Accordingly, a visual colorimetric method for the detection of methanol based hand sanitizers and also for the semi-quantitative determination of ethanol or propanol in ethanol or propanol based products is developed. Methanol based sanitizers pose a serious threat to human health while ethanol or propanol based sanitizers containing <60% (v/v) alcohol are poor disinfectants. Taking cognizance of the fact that alcohol and water account for >95% volume of sanitizers, the method utilizes the alcohol dependent miscibility of alcoholwater binary mixtures in n-butyl acetate for analysis. The phase separations in the alcohol:water:n-butyl acetate ternary mixtures are quantitatively identified through colour contrast developed by the addition of crystal violet. The method has been applied to several commercially available liquid and also gel type sanitizers. It works well for colorless as well as coloured sanitizers. It is simple and can be used for selecting the right kind of hand sanitizers.

 
 
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