The flux-weighted average cross sections of ^natIn(γ, xn) reactions and isomeric yield ratios of ^112m,gIn, ^111m,gIn, and ^110m,gIn were measured with the bremsstrahlung end-point energies of 50, 60, and 70 MeV using an activation and off-line γ-ray spectrometric technique at the Pohang Accelerator Laboratory (PAL), Korea. It was observed that the average cross sections of the ^natIn(γ, xn) Reactions increase with bremsstrahlung energy up to the Gaint Dipole Resonance (GDR) region. Thereafter, it shows a small decrease trend with bremsstrahlung energy due to the opening of another reaction channel. The isomeric yield ratios of same product in the (γ,n), (n,2n), (p,x), (α,x), and (³He,x) reactions for various targets show that the spin of the target nucleus plays a vital role besides the effect of excitation energy and input angular momentum in determining the isomeric yield ratios.