Mixed-matrix membranes (MMMs) were developed by impregnating organofunctionalized nanoadditives within fouling-susceptible polysulfone matrix following the nonsolvent induced phase separation (NIPS) method. The facile functionalization of nanoparticles of anatase TiO₂ (nano-TiO₂) by using two different organoligands, viz. Tiron and chromotropic acid, was carried out to obtain organofunctionalized nanoadditives, F_T-nano-TiO₂ and F_C-nano-TiO₂, respectively. The structural features of nanoadditives were evaluated by X-ray diffraction, X-ray photoelectron spectroscopy, Raman and Fourier transform infrared spectroscopy, which established that Tiron leads to the blending of chelating and bridging bidentate geometries for F_T-nano-TiO₂, whereas chromotropic acid produces bridging bidentate as well as monodentate geometries for F_C-nano-TiO₂. The surface chemistry of the studied membranes, polysulfone (Psf): F_T-nano-TiO₂ UF and Psf: F_C-nano-TiO₂ UF, was profoundly influenced by the benign distributions of the nanoadditives enriched with distinctly charged sites (–SO⁻₃ H⁺), as evidenced by superior morphology, improved topography, enhanced surface hydrophilicity and altered electrokinetic features. The membranes exhibited enhanced solvent throughputs, viz. 3500–4000 and 3400–4300 LMD at 1 bar of transmembrane pressure, without significant compromise in their rejection attributes. The flux recovery ratios and fouling resistive behaviours of MMMs towards bovine serum albumin indicated that the nanoadditives could impart stable and appreciable antifouling activity, potentially aiding in a sustainable ultrafiltration performance.