Nucleon knockout experiments using beryllium or carbon targets reveal a strong dependence of the quenching factors, i.e., the ratio (R_s ) of theoretical to the experimental spectroscopic factors (C²S), on the proton-neutron asymmetry in the nucleus under study. However, this depen-dence is greatly reduced when a hydrogen target is used. To understand this phenomenon, exclusive ¹H(¹⁷ Ne, 2p ¹⁶ F) and inclusive ¹²C(¹⁷ Ne, 2p ¹⁶F)X, ¹²C(¹⁷Ne, ¹⁶F)X as well as ¹H(¹⁷Ne,¹⁶F)X (X-denotes undetected reaction products) reactions with ¹⁶ F in the ground and excited states were analysed. The longitudinal momentum distribution of ¹⁶F and the correlations between the detached protons were studied. In the case of the carbon target, there is a significant devia-tion from the predictions of the eikonal model. The eikonal approximation was used to extract spectroscopic factor val-ues C²S. The experimental C²S value obtained with C target is markedly lower than that for H target. This is interpreted as rescattering due to simultaneous nucleon knockout from both reaction partners, ¹⁷Ne and ¹²C.