The independent isomeric yield ratios (IR) for the ^139m,gNd and the ^141m,gNd isomeric pairs produced from the ^natNd(γ, xn) reactions were determined by the activation and the off-line γ-ray spectrometric technique at the end-point bremsstrahlung energies of 45, 50, 55, and 60 MeV in the 100 MeV electron Linac of the Pohang accelerator laboratory, Korea. The present IR for the ^141m,gNd isomeric pair were compared with those from the literature measured by the bremsstrahlung and the neutron to examine the role of excitation energy. The obtained IR for the ^139m,gNd and the ^141m,gNd isomeric pairs from ^natNd(γ, xn) reactions were compared with those from the ¹⁴¹Pr(p, x), the ^natCe(³He, x), and the ¹³⁶Ce(α n) reactions to examine the role of parameters in entrance channel i.e. excitation energy and the effect of the input angular momentum. The present IR of ^139m,gNd and ^141m,gNd were compared with those calculated by using the TALYS 1.4 code as well as those from the literature data of above mentioned reactions.