An innovative hydrometallurgical process flowsheet comprising of 'oxidative alkaline pressure leaching–counter-current filtration direct precipitation–reagent regeneration cum recycle' was developed for effective recovery of the uranium values from a low-grade dolostone hosted stratabound type uranium ore deposit in Southern Cuddapah basin of India. Many challenges inherent in the ore like: lean-tenor (U₃O₈ about 0·04%), absence of discrete uranium phases, distribution of majority of uranium values (about 90% by weight) as ultra-fine dissemination in carbonate matrix and presence of reactive sulphide minerals, were converted into portunities leading to establishment of a process plant after elaborate laboratory and pilot-plant investigations. This paper iscusses he results of the laboratory and pilot-plant investigations arried out for development of the process flowsheet.