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Author(s) |
Kasaliwal, R.; Malhotra, G.;, Lila, A.; Bandgar, T.; Shah, N. S. (RMC)
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Source |
Clinical Nuclear Medicine, 2015. Vol. 40 (5): pp. 439-441 |
ABSTRACT
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Paragangliomas (PGLs) due to succinate dehydrogenase subunit B (SDH-B) mutation can be aggressive. A 40-year-old woman with normetanephrine-secreting, extra-adrenal, abdominal PGL due to SDH-B genetic mutation underwent surgical excision of primary, followed by whole-body 131I-MIBG scan after 6 months, which showed no abnormality. However, 68Ga-DOTANOC and 18F-FDG PET/CT scans showed primary site recurrence, hepatic and skeletal metastasis, with latter scan revealing more lesions. We suggest that 18F-FDG PET should be done in all patients with PGL due to SDH-B mutations, as it may show additional unsuspected lesions that may be missed by other tracers. |
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