BARC/PUB/2015/1058

 
 

Comparison of 131I-MIBG, 68Ga-DOTANOC PET/CT and 18F-FDG PET/CT scans in a patient with extra adrenal paraganglioma associated with SDH-B gene mutation

 
     
 
Author(s)

Kasaliwal, R.; Malhotra, G.;, Lila, A.; Bandgar, T.; Shah, N. S.
(RMC)

Source

Clinical Nuclear Medicine, 2015. Vol. 40 (5): pp. 439-441

ABSTRACT

Paragangliomas (PGLs) due to succinate dehydrogenase subunit B (SDH-B) mutation can be aggressive. A 40-year-old woman with normetanephrine-secreting, extra-adrenal, abdominal PGL due to SDH-B genetic mutation underwent surgical excision of primary, followed by whole-body 131I-MIBG scan after 6 months, which showed no abnormality. However, 68Ga-DOTANOC and 18F-FDG PET/CT scans showed primary site recurrence, hepatic and skeletal metastasis, with latter scan revealing more lesions. We suggest that 18F-FDG PET should be done in all patients with PGL due to  SDH-B mutations, as it may show additional unsuspected lesions that may be missed by other tracers.

 
 
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