Road dust samples were collected in different locations of heavy traffic, medium traffic, express way and industrial areas of Mumbai. The concentrations of various elements (Mg, Al, K, Ca, Ti, V, Cr, Mn, Fe, Co, Ni, Cu, Zn and Pb) in road dust samples were analyzed using EDXRF. The average elemental profile of road dust in Mumbai was comparable with studies carried out in other countries with slight variations. The estimated geo accumulation indices and enrichment factors indicated moderate elemental contamination and enrichment of anthropogenic elements in road dust samples. Factor analysis of elemental data resolved four sources namely crustal, tyre wear, vehicular/industrial emissions and break wear.