MgO nanoparticle loaded mesoporous alumina has been synthesized using a simple aqueous solutionbased cost effective method for removal of fluoride from water. Wide angle powder X-ray diffraction,nitrogen adsorption desorption analysis, transmission electron microscopy techniques and energy dis-persive X-ray spectroscopy were used to characterize the synthesized adsorbents. Synthesized adsorbentspossess high surface area with mesoporous structure. The adsorbents have been thoroughly investigatedfor the adsorption of F−using batch adsorption method. MgO nanoparticle loading on mesoporous Al₂O₃ enhances the F−adsorption capacity of Al₂O₃from 56% to 90% (initial F−concentration = 10 mg L⁻¹).Kinetic study revealed that adsorption kinetics follows the pseudo-second order model, suggestingthe chemisorption mechanism. The F−adsorption isotherm data was explained by both Langmuir andFreundlich model. The maximum adsorption capacity of 40MgO@Al₂O₃ was 37.35 mg ^g−1. It was alsoobserved that, when the solutions having F−concentration of 5 mg L⁻¹ and 10 mg L⁻¹ was treated with 40MgO@Al₂O₃, the F−concentration in treated water became <1 mg L⁻¹, which is well below the recom-mendation of WHO.