The excitation function for the proton induced nuclear reactions on natural cadmium was measured up to 23 MeV employing stacked foil activation technique using the 14UD pelletron accelerator. Experimental cross-section and isomeric cross-section ratio have been measured for the nat Cd(p,x)^{109_g,110_m,110_g,111_m,111_g,112_m,112_g,113_m,115_m,116_m} In reactions. The excitation func-tion of ¹⁰⁵ Cd and the isomeric cross-section ratio of ^{110 ,111,112} In isotopes have been measured and reported for the first time. Theoretical analysis of the data are done using the statistical model codes EMPIRE-3.2 and TALYS-1.8. Various dependence of isomeric cross-section ratio on different factors such as the spin, life time of the isomeric states and also the depen-dence of the exit channel are well explained