Two procedures for fixing the¹²⁵I activity on different matrices were explored. In the first method, anodic deposition of ¹²⁵I on silver wire was used. In the second, ¹²⁵I was adsorbed as iodate (IO₃^—) on alumina microspheres by using a solid-solution interface technique. While the ¹²⁵I uptake was ~84% on the silver wires by electrodeposition method, the microspheres showed ~97% by the solid-solution interface technique. The low leachable (0.05%) wires, and comparatively high leachable (~4%) spheres were trial encapsulated and laser welded. The encapsulated sources were measured for source strength and were found to be suitable for the treatment of eye cancer.