The article gives the summary of our R&D contributions of in situ current normalized particle induced gamma-ray emission (PIGE) method utilizing proton beams from accelerators to quantify low Z elements from Li to Ti in various samples. Measurement of prompt gamma-rays from proton induced reactions was performed by HPGe detector system coupled to MCA. PIGE methods were utilized for non-destructive quantification of low Z elements in glass, ceramics like lithium titanate, Li-ion batteries and archaeological artifacts, environmental and food samples, and simultaneous quantification of total B and its isotopic composition in boron-based neutron absorbers, alloys and refractory materials.