BARC/PUB/2019/0705

 
 

Spectro-electrochemistry of ciprofloxacin and probing its interaction with bovine serum albumin

 
     
 
Author(s)

Ipte, P. R.; Sahoo, S.; Satpati, A. K.
(ACD)

Source

Bioelectrochemistry, 2019. Vol. 130: Article no. 107330

ABSTRACT

In the present investigation the electrochemical behaviour of the drug, Ciprofloxacin (Cf) and its interactionwith the Bovine Serum Albumin (BSA) is reported. UV-Visible Spectroscopy (UV-Vis) and Spectro-electrochemical measurements were carried out to quantify the charge transfer process in Cf. Analysis of the results obtained from cyclic voltammetry (CV) measurements indicated the electrochemical oxidation of Cf followed mixed adsorption and diffusion control process. The spectro-electrochemical investigationswere carried out and themodification of the spectral peakswere monitored to obtain the mechanismof the electrochemical oxidation process of Cf. Interaction of Cf with Bovine SerumAlbumin (BSA)were investigated using electrochemical, spectroscopic and spectro-electrochemical experiments. Important electro-kinetic parameters like; the electron transfer property, binding constant and diffusivity of the Cf/BSA complex were investigated. Electrochemistry with an ultramicroelectrode was utilised to investigate the diffusivity of the drug and its complex with BSA, which supports the strong binding of Cf with BSA.

 
 
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