The applicability of conventional spray dryer was studied to prepare micro as well as nano carriers. Using spray drying technique rhodamine B (RhB) loaded nanosilica-sodium alginate microstructures (RhBmicrostructures) was prepared. For the preparation of nanobeads, nozzle (atomizer) of spray dryer was used to spray the feed comprising RhB-nanosilica-sodium alginate in the calcium chloride solution and RhB loaded nanosilica-calcium alginate nanobeads (RhB-nanobeads) were obtained. Prepared carriers (RhB-microstructures and RhB-nanobeads) were characterized using SEM, FTIR, DLS and Zeta potential techniques. The flowability of prepared carriers were studied using compressibility index (C.I.) and Hausner ratio (H.R.). RhB-microstructures showed a higher loading efficiency 98.6% in comparison to 46.7% of RhB-nanobeads. In vitro release study demonstrated slow and pH-responsive release of RhB from nanobeads. Present study shows the applicability of conventional spray drying and use of spraying nozzle of conventional spray dryer to prepare microstructures and nanobeads, respectively.