Shakedown and ratcheting behaviour of thick cylinder with multiple radial crossholes is investigated in this paper by inelastic finite element analysis. Effect of opening radius (r_i/R_i), thickness of the vessel i.e. thickness ratios (R_o/R_i) and availability of ligament between two openings (L/t) is studied. In order to normalise the applied pressure, limit load for thick cylindrical vessel without any opening was considered and it was found to be highly conservative. Later, interaction diagram normalised with respect to the limit load for thick cylinder taking into account the effects of opening was plotted. In order to distinguish between plastic shakedown and ratcheting, thickness advantage is taken into consideration. A more practical assessment technique is also discussed where the maximum range of thermal stress is computed through finite element analysis and the results were found to be in accordance with the Bree diagram. However the elastic-plastic shakedown boundary was found to be affected significantly with the incorporation of discontinuities and with changes in the parameters.