The medical isotopes ⁹⁹Mo and ⁶⁴Cu were produced via the dual routes of ¹⁰⁰Mo(γ,n)⁹⁹Mo + ⁹⁸Mo(n,γ)⁹⁹Mo and ⁶⁵Cu(γ,n) ⁶⁴Cu + ⁶³Cu(n,γ)⁶⁴Cu reactions from ^natMo and ^natCu targets via irradiation with bremsstrahlung + neutrons field using a 15MV clinical electron linear accelerator (linac). The activities of ⁹⁹Mo and ⁶⁴Cu measured by off-line γ-ray spectrometry were 1.05 and 13.5 Bq per gram of natMo and natCu per gray-second irradiation. Fluka calculations estimate 28.77 ± 5.5 and 33.35 ± 6.33% contribution to ⁹⁹Mo and ⁶⁴Cu yield, respectively due to the secondary co-produced neutrons by (γ,n) reactions in the linac head. The 64Cu yield is observed to increase up to 46% after moderation of the neutrons with varying thickness of a solid water phantom. This study suggests the possibility of irradiating natural targets of Mo and Cu in an electron linac to produce ⁹⁹Mo and ⁶⁴Cu as a cost saving measure for medical applications.