Removal of a thin oxide layer from a tungsten ribbon was achieved using the fundamental, second andthird harmonic radiation from a Q- switched Nd-YAG laser. It was found that beyond the threshold, oxideremoval was achieved at all wavelengths for a wide range of fluence values. The removal mechanismof the oxide layer was found to be critically dependent on both wavelength and fluence of the incidentradiation and has been identified as ejection or sublimation. The un-cleaned and cleaned surfaces wereanalyzed by scanning electron microscopy (SEM), energy dispersive X-ray analysis (EDS) and atomic forcemicroscopy (AFM). Laser cleaned tungsten ribbons were used in a thermal ionization mass spectrometer(TIMS) to determine isotopic composition of Neodymium atoms.