The ability of polyanionic molybdate to inhibit and degrade protein in vitro (insulin protein) and in vivo (Drosophila fly model) has been demonstrated. We establish the disappearance of fibrillar structures and recovery from eurodegenerative disorders in molybdate-treated Aβ42-mutant Drosophila flies as compared to the untreated ones, corroborating the therapeutic ability of ammonium molybdate towards the treatment of Alzheimer’s disease.