BARC/PUB/2013/0503

 
 

Gratifying clinical experience with an indigenously formulated single-vial lyophilized HYNIC-TOC kit at the radiopharmaceutical division of BARC: a pivotal boost for building up a peptide receptor radionuclide therapy programme in an Indian setting

 
     
 
Author(s)

Basu, S.; Kand, P.; Mallia, M.; Korde, A.; Shimpi, H.
(RMC)

Source

European Journal of Nuclear Medicine & Molecular Imaging, 2013. Vol. 40 (10): pp. 1622-1624

ABSTRACT

Peptide receptor radionuclide therapy (PRRT) with 177Lubased somatostatin receptor analogues has seen a rapid expansion and has generated significant interest over recent years amongst the nuclear medicine fraternity. In India, this has received a major boost in recent years. The primary impetus for this could be ascribed to two developments as a part of radiopharmaceutical research in the country’s premier atomic energy establishment Bhabha Atomic Research Centre (BARC): (1) the availability of 177Lu-LuCl3 at a much lower cost due to indigenous production (less than one-third of commercially available material) and (2) indigenous production of a single-vial kit for the formulation of 99mTc-HYNIC-TOC, which has played an important role in centres that do not have access to a germanium/gallium generator. Both these developments at the Radiopharmaceutical Division of BARC could be considered major societal contributions to radiopharmaceutical  research in this country in recent years that has benefited a large number of patients with neuroendocrine tumours of various subtypes, both from a diagnostic and a therapeutic standpoint, in multiple clinical centres active in this domain.

 
 
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