The title compound has been synthesized by a facile route starting from 4-pentyn-1-ol. The enantioselectivity was at-tained by a strategy involving a lipase-catalyzed acetylation of a solid-phase immobilized long chain α-hydroxy acid. Another im-portant feature of the synthesis was the formulation of an efficient HgO-catalyzed O-methylation of the α-hydroxy acids which pro-ceeded without any racemization. The alkylation protocol was also highly efficient for selective mono-methylation/benzylation of symmetrical diols.