2-propanone is a commonly-used chemical and is a biomarker of diabetic ketoacidosis. Herein, thedevelopment of a novel stand-alone chemiresistive sensor with high sensitivity and selectivity for 2-propanone is reported. Fluorocarbon elastomer (FCE)/nanocarbon black (NCB) conducting compositesbased chemiresistors with different crosslinking densities were synthesized via melt compounding followed by radiation crosslinking. Conducting composites in different parts of the percolation profile werechosen to establish the dependence of 2-propanone sensing response on the conducting network and theradiation cross-linked network. The chemiresistor showed a highly selective response for 2-propanonewhereas a considerably lower response was noted for benzene, toluene, xylene, ethanol, methanol andwater. The sensing response had a strong correlation with the FCE-analyte interaction parameter (X₁₂).