The most important non-functional requirements for dependability of any Embedded Real-Time Safety Systems are safety, availability and reliability requirements. System architecture plays the primary role in achieving these requirements. Compliance with these non-functional requirements should be ensured early in the development cycle with appropriate considerations during architectural design. In this paper, we present an application of system architecture modeling for quantitative assessment of system dependability. We use probabilistic model checker (PRISM), for dependability analysis of the DTMC model derived from system architecture model. In general, the model checking techniques do not scale well for analyzing large systems, because of prohibitively large state space. It limits the use of model checking techniques in analyzing the systems of practical interest. We propose abstraction based compositional analysis methodology to circumvent this limitation. The effectiveness of the proposed methodology has been demonstrated using the case study involving the dependability analysis of safety system of a large Pressurized Water Reactor (PWR).