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| Author(s) |
Chakravarty, R.; Dash, A.; Kothari, K.; Pillai, M. R. A.; Venkatesh, M.
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Rhenium-188 is a well recognized therapeutic radionuclide and its
use in a variety of applications has been reported. The
current methods of obtaining “no-carrier added” 188Re from
conventional alumina based generators require 188W of
very high specific activity for obtaining reasonable quantities of
188Re in an adequately concentrated form. We have
developed a simple electrochemical separation technique adaptable
for using low specific activity 188W, for the separation
of 188Re from 188W, and obtain 188Re
amenable for radio labeling biomolecules. The overall decay
corrected yield of 188Re was > 70%. The recovered
188Re had high radiochemical (> 97%) and radionuclidic purity
(> 99.99%). The suitability of the 188Re for
radiolabeling was demonstrated by its use for the complexation of
DMSA and HEDP with labeling yields > 98%. Repeated separation of
188Re from a stock solution of 188W could be
demonstrated for a period of 70 d. The preliminary results suggest
that the process can be scaled up to higher activity levels and
suggest that this strategy can be further explored for the
development of electrolytic type 188W/188Re
generator suitable for clinical applications. |
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